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Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice.
(Elsevier., 2007-06)
During aging the hippocampus experiences structural, molecular, and functional alterations. Protection from age-related disorders is provided by several factors, including estrogens. Since aging defects start at middle ...
Serum-induced neurite retraction in CAD cells – involvement of an ATP-actin retractile system and the lack of microtubule-associated proteins
(Wiley Blackwell Publishing, Inc, 2014-10)
Cultured catecholamine-differentiated cells [which lack the microtubule-associated proteins (MAPs): MAP1B, MAP2, Tau, STOP, and Doublecortin] proliferate in the presence of fetal bovine serum, and, in its absence, cease ...
The selective glucocorticoid receptor modulator CORT108297 restoresfaulty hippocampal parameters in Wobbler andcorticosterone-treated mice
(Elsevier, 2014-09)
Mutant Wobbler mice are models for human amyotrophic lateral sclerosis (ALS). In addition to spinal cord degeneration, Wobbler mice show high levels of blood corticosterone, hyperactivity of the hypothalamic-pituitary-adrenal ...
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
(Elsevier Inc, 2014-11-15)
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this ...
Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
(Wiley, 2013-02-24)
It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology ...
Activation of the G Protein-Coupled Estrogen Receptor (GPER) Increases Neurogenesis and Ameliorates Neuroinflammation in the Hippocampus of Male Spontaneously Hypertensive Rats
(Springer/Plenum Publishers, 2019-11)
It is known that spontaneously hypertensive rats (SHR) present a marked encephalopathy, targeting vulnerable regions such as the hippocampus. Abnormalities of the hippocampus of SHR include decreased neurogenesis in the ...
Sexually dimorphic expression of receptor-alpha in the cerebral cortex of neonatal Caiman latirostris (Crocodylia, Aligatoridae)
(Academic Press Inc Elsevier Science, 2012-11)
In mammals, estrogens have been described as endocrine and paracrine modulators of neuronal differentiation and synapse formation. However, the functional role of circulating estrogens and the distribution of estrogen ...
17α-Oestradiol-induced neuroprotection in the brain of spontaneously hypertensive rats
(Wiley, 2014-04-14)
17β-oestradiol is a powerful neuroprotective factor for the brain abnormalities of spontaneously hypertensive rats (SHR). 17α-Oestradiol, a nonfeminising isomer showing low affinity for oestrogen receptors, is also endowed ...
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats
(Mary Ann Liebert, 2020-12)
Several countries have established self-help cryonics groups whose mission is to cryopreserve human bodies or brains after legal death and ship them to cryonics organizations. The objective of this study was to report the ...
A single dose of 5-MeO-DMT stimulates adult neurogenesis in mouse dentate gyrus
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM PSICOBIOLOGIA, 2018-05-24)
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few brain regions in
which neurogenesis is maintained throughout adulthood. It is believed that newborn neurons in
this region encode temporal information ...