Artículos de revistas
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
Fecha
2014-11-15Registro en:
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-97
0165-5728
Autor
Garay, Laura Ines
Gonzalez Deniselle, Maria Claudia
Sitruk Ware, Regine
Gennoun, Rachida
Shumacher, Michael
Alejandro de Nicola
Resumen
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.