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Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
(Wiley Blackwell Publishing, Inc, 2020-09)
Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised ...
Exploring the landscape of diazabicyclooctane (DBO) inhibition: Avibactam inactivation of PER-2 β-Lactamase
(American Society for Microbiology, 2017-06)
PER β -lactamases are an emerging family of extended-spectrum β -lactamases (ESBL) found in Gram-negative bacteria. PER β -lactamases are unique among class A enzymes as they possess an inverted omega (?) loop and extended ...
Structural and biochemical characterization of the novel CTXM-151 extended-spectrum β-lactamase and its inhibition by avibactam
(American Society for Microbiology, 2021-04)
The diazabicyclooctane (DBO) inhibitor avibactam (AVI) reversibly inactivates most serine β-lactamases, including the CTX-M β-lactamases. Currently, more than 230 unique CTX-M members distributed in five clusters with less ...
Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed blaPDC in a Hollow-Fiber Infection Model
(American Society for MicrobiologyAntimicrobial Agents and Chemotherapy, 2021)
La ceftazidima (CAZ)-avibactam (AVI) es una combinación de β-lactámico/inhibidor de la β-lactamasa con actividad frente a las β-lactamasas de tipo A y C. Se ha observado la aparición de resistencias por múltiples mecanismos. ...
Bacteremias por Klebsiella pneumoniae : epidemiologia, clínica e mecanismos de resistência microbiana
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Medicina Tropical, 2019)
Population Structure, Molecular Epidemiology, and beta-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States
(American Society for Microbiology, 2019-07)
Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus that is an important cause of nosocomial infections, primarily associated with the respiratory tract in the immunocompromised population. ...
Consumo de antimicrobianos en hospital de tercer nivel durante el periodo 2020-2022.
(Universidad Católica de Santiago de Guayaquil, 2023)
Caracterización clínica-microbiológica y factores de riesgo de las bacteriemias por enterobacterias productoras de betalactamasas de espectro extendido en el hospital universitario
(Udelar. FM, 2022)
INTRODUCCIÓN: Las infecciones del torrente sanguíneo se asocian con alta morbi- mortalidad, siendo frecuentemente causadas por enterobacterias, y cuando éstas producen β-lactamasas de espectro extendido (BLEEs), la ...