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Alpha9 nicotinic acetylcholine receptors and the treatment of pain
(Pergamon-Elsevier Science Ltd, 2009-10)
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular ...
Disruption of 5-HT2A Receptor-PDZ Protein Interactions Alleviates Mechanical Hypersensitivity in Carrageenan- Induced Inflammation in Rats
(Plos One, 2013)
Despite common pathophysiological mechanisms, inflammatory and neuropathic pain do not respond equally to the
analgesic effect of antidepressants, except for selective serotonin reuptake inhibitors (SSRIs), which show a ...
Ação da Phα1β, peptídeo purificado do veneno da aranha Phoneutria nigriventer, sobre os efeitos analgésicos e adversos causados pela morfina em camundongos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2015-06-19)
Opioids are the most common drugs prescribed worldwide for alleviating moderate to
severe pain. However, the use of opioids is associated with the development of
tolerance to the analgesic effect and potential adverse ...
Fórmula magistral gel apitoxina para tratamiento de artritis para uso con guante térmico
(Corporación Tecnológica de BogotáNo aplicaBogotá, 2018)
La apitoxina es el componente principal que proviene del veneno de las abejas, purificado mediante procesos específicos, se eliminan componentes no benéficos del veneno, tales como aceites volátiles, lípidos y pretinas. ...
Participação dos sistemas opioidérgico e canabi-noidérgico na modulação endógena periférica da dor inflamatória muscular
(Universidade Federal de Minas GeraisUFMG, 2015-08-28)
Pain processing starts from a noxious stimulus able to sensitize nociceptor peripheral terminals. Pain information converges from the periphery to the dorsal horn of the spi-nal cord through fibers type A, A and C. Once ...
Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain
(2013-06-17)
Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American ...