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Designing improved active peptides for therapeutic approaches against infectious diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major ...
Cationic antimicrobial peptides inactivate shiga toxin-encoding bacteriophages
(Frontiers Media S.A., 2018)
Shiga toxin (Stx) is the principal virulence factor during Shiga toxin-producing Escherichia coli (STEC) infections. We have previously reported the inactivation of bacteriophage encoding Stx after treatment with chitosan, ...
Combinatorial synthesis and directed evolution applied to the production of alpha-helix forming antimicrobial peptides analogues
(Bentham Science Publ Ltd, 2006-12-01)
Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in different groups of organisms, including microorganisms, plants, insects, amphibians and humans. These peptides exhibit several structural ...
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates
(Elsevier Masson, 2013-11)
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo ...
Identification of peptides in flowers of Sambucus nigra with antimicrobial activity against aquaculture pathogens
(MDPI, 2018-05)
The elder (Sambucus spp.) tree has a number of uses in traditional medicine. Previous studies have demonstrated the antimicrobial properties of elderberry liquid extract against human pathogenic bacteria and also influenza ...
Contribution of the tyr-1 in plantaricin149a to disrupt phospholipid model membranes
(MDPI AGBasel, 2013-06)
Plantaricin149a (Pln149a) is a cationic antimicrobial peptide, which was suggested to cause membrane destabilization via the carpet mechanism. The mode of action proposed to this antimicrobial peptide describes the induction ...
Effects of Dimerization on the Structure and Biological Activity of Antimicrobial Peptide Ctx-Ha
(Amer Soc Microbiology, 2012-06-01)
It is well known that cationic antimicrobial peptides (cAMPs) are potential microbicidal agents for the increasing problem of antimicrobial resistance. However, the physicochemical properties of each peptide need to be ...
Effects of Dimerization on the Structure and Biological Activity of Antimicrobial Peptide Ctx-Ha
(Amer Soc Microbiology, 2012-06-01)
It is well known that cationic antimicrobial peptides (cAMPs) are potential microbicidal agents for the increasing problem of antimicrobial resistance. However, the physicochemical properties of each peptide need to be ...
Antimicrobial Peptides as an Alternative for the Eradication of Bacterial Biofilms of Multi-Drug Resistant Bacteria
(2022-03-01)
Bacterial resistance is an emergency public health problem worldwide, compounded by the ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World Health Organization has published a ...