Artículos de revistas
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates
Fecha
2013-11Registro en:
Faccone, Diego Francisco; Semorile, Liliana Carmen; Maffia, Paulo Cesar; Martínez, Melina María Belén; Noguera, Martín Ezequiel; Corso, Alejandra; et al.; Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates; Elsevier Masson; European Journal of Medical Chemistry; 71; 11-2013; 31-35
0223-5234
CONICET Digital
CONICET
Autor
Faccone, Diego Francisco
Veliz, Omar
Corso, Alejandra
Noguera, Martín Ezequiel
Martínez, Melina María Belén
Payés, Cristian
Semorile, Liliana Carmen
Maffia, Paulo Cesar
Resumen
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).