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In vitro and in vivo assessment of the benzydamine-mediated interference with the hepatic S-oxidation of the anthelmintic albendazole in sheep
(Elsevier Science, 2014-04)
The aim of this research was to investigate the influence of benzydamine (BZ) on the in vitro and in vivo hepatic metabolism of the anthelmintic albendazole (ABZ) in sheep. The enantioselective ABZ S-oxidation was assessed ...
Albendazole treatment in laying hens: Egg residues and its effects on fertility and hatchability
(Wiley Blackwell Publishing, Inc, 2018-10)
This work characterized the egg residual concentrations of albendazole (ABZ) and its sulphoxide (ABZSO) and sulphone (ABZSO2) metabolites and evaluated their effect on egg fertility and hatchability after ABZ treatments ...
A nanocrystal-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2018-01-16)
We aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. Methods: In the pharmacokinetic study, ABZ self-dispersible ...
Dose-dependent systemic exposure of albendazole metabolites in lambs
(Wiley Blackwell Publishing, Inc, 2012-08)
The gastrointestinal absorption of most drugs follows a first-order kinetics, whereby a constant fraction of the total drug is absorbed in each equal time interval. Although this related absorption principle is applicable ...
Testing albendazole resistance in Fasciola hepatica: validation of an egg hatch test with isolates from South America and the United Kingdom
(Cambridge University Press, 2013-03)
The main goal of the current work was to develop and validate an in vitro fluke egg hatch test, as a method for the detection of albendazole (ABZ) resistance in the liver fluke, Fasciola hepatica. Fluke eggs (200/ml, n ...
Avaliação na redução de ovos de nematódeos gastrintestinais em bovinos após a administração de anti-helmínticos
(2010-11-17)
To evaluate the necessary time and to identify the differences among anthelmintics for the reduction of parasite eggs shed in feces, five groups of cattle were treated with moxidectin, ivermectin, levamisole phosphate, and ...
Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers
(Public Library of Science, 2018-01)
Background: Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug ...
Metabolismo in vitro do albendazol em escala miligrama e purificação por cromatografia líquida de alta eficiência semipreparativa
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2012-06-06)
This work presents the in vitro metabolism of albendazole (ABZ) conducted with microsomal fractions obtained from Wistar rats and performed in analytical and semipreparative scale. Subsequent separation and purification ...