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Molecular basis of ligand dissociation in β-adrenergic receptors
(Public Library of Science, 2011)
The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand ...
Sucinato melhora a memória da tarefa de medo condicionado em ratos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2007-07-03)
Succinate is a dicarboxylic acid that accumulates due to succinate dehydrogenase inhibition. This dicarboxylic acid has a biphasic effect on neural activity in vitro that seems to be
mediated by N-methyl-D-aspartate (NMDA) ...
Differential β₂-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines
(Impact Journals, 2014-11-07)
Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused ...
Blocking of β-adrenergic receptors during the subfertile period inhibits spontaneous ovarian cyst formation in rats
(2012)
As aging proceeds, fertility problems arise, and the success rate of in vitro fertilization declines. During reproductive aging, rat ovaries present spontaneous formation of cysts, followed by a concomitant increase in ...
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles
(MDPI AG, 2018)
© 2018 by the authors. The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and ...