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T-cell receptor cognate target prediction based on paired α and β chain sequence and structural CDR loop similarities
(Frontiers Media, 2019-08)
T-cell receptors (TCR) mediate immune responses recognizing peptides in complex with major histocompatibility complexes (pMHC) displayed on the surface of cells. Resolving the challenge of predicting the cognate pMHC target ...
Evolución de los determinantes estructurales de la especificidad de sustratos en la familia 6-fosfogluconato deshidrogenasa
(Universidad de Chile, 2014)
La superfamilia β-hidroxiácido deshidrogenasas (βHADH) son enzimas oligoméricas que catalizan la oxidación dependiente de NAD o NADP de diversos β-hidroxiácidos (βHA). Cada subunidad está compuesta por un dominio N-terminal ...
Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function
(Wiley VCH Verlag, 2013-05)
Viral double-stranded RNA (dsRNA) mimetics have been explored in cancer immunotherapy to promote antitumoral immune response. Polyinosine–polycytidylic acid (poly I:C) and polyadenylic–polyuridylic acid (poly A:U) are ...
Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells
(Wiley-liss, Div John Wiley & Sons Inc, 2017-08)
Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP‐regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those ...
A Novel Missense Mutation in the HSD3B2 Gene, Underlying Nonsalt-Wasting Congenital Adrenal Hyperplasia. New Insight Into the Structure-Function Relationships of 3β-Hydroxysteroid Dehidrogenase Type II
(Endocrine Society, 2015-01)
Context: 3βHSD2 is a bifunctional microsomal NAD+-dependent enzyme crucial for adrenal and gonad steroid biosynthesis, converting Δ5-steroids to Δ4-steroids. 3βHSD2 deficiency is a rare cause of congenital adrenal hyperplasia ...
The twisted survivin connection to angiogenesis
(2015)
Abstract
Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human cancers. As ...
The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop
(American Society for Microbiology, 2018-12)
Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of ...
Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2β protein in patients with chronic Chagas' heart disease
(Wiley Blackwell Publishing, Inc, 2004-06)
High levels of antibodies against the C-terminus of the Trypanosoma cruzi TcP2β ribosomal protein, defined by the peptide EEEDDDMGFGLFD, named R13, have been measured in sera from patients with chronic Chagas' Heart Disease ...
Crystal structure and kinetic analysis of the class B3 di-zinc metallo-β-lactamase LRA-12 from an Alaskan soil metagenome
(Public Library of Science, 2017-07)
We analyzed the kinetic properties of the metagenomic class B3 β-lactamase LRA-12, and determined its crystallographic structure in order to compare it with prevalent metallo-β-lac-tamases (MBLs) associated with clinical ...
Comments on two-loop Kac-Moody algebras
(Elsevier B.V., 1992-12-01)
It is shown that the two-loop Kac-Moody algebra is equivalent to a two-variable-loop algebra and a decoupled β-γ system. Similarly WZNW and CSW models having as algebraic structure the Kac-Moody algebra are equivalent to ...