Buscar
Mostrando ítems 21-30 de 344
Geoffroea decorticans fruit extracts inhibit the wnt/β-catenin pathway, a therapeutic target in cancer
(Academic Press Inc Elsevier Science, 2021-03)
Geoffroea decorticans (chañar) is commonly used for culinary and medicinal purposes in rural communities. The aim of this work was to chemically characterize three Geoffroea decorticans extracts and determine their capacity ...
Parsing β-catenin’s cell adhesion and Wnt signaling functions in malignant mammary tumor progression
(National Academy of Sciences, 2021-08)
During malignant progression, epithelial cancer cells dissolve their cell–cell adhesion and gain invasive features. By virtue of its dual function, β-catenin contributes to cadherin-mediated cell–cell adhesion, and it ...
Wnt/β-catenin pathway in the prefrontal cortex is required for cocaine-induced neuroadaptations
(Wiley Blackwell Publishing, Inc, 2017-07)
Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can be divided into two distinct temporal and anatomical domains, ...
Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity
(2011)
β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the ...
Aberrant expression of E-cadherin/β-catenin during epidermal tumourigenesis in dogs
(Elsevier, 2020-04)
Clinically relevant epidermal tumours in dogs include cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs). The development of CPs and CSCCs involves dysregulation in expression of E-cadherin/β-catenin; ...
Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization in rats
(Pergamon-Elsevier Science Ltd, 2017-10)
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2 mg/kg of GBH from ...
TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway
(2011)
Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin ...
HER2 and ß-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations
(Springer, 2015-02)
In human breast cancer, β-catenin localization has been related with disease prognosis. Since HER2-positive patients are an important subgroup, and that in breast cancer cells a direct interaction of β-catenin/HER2 has ...
Deregulation of E-cadherin, β-catenin, APC and Caveolin-1 expression occurs in canine prostate cancer and metastatic processes
(2018-06-01)
Prostate cancer is a heterogeneous disease with high levels of clinical and gene heterogeneity, consequently offering several targets for therapy. Dogs with naturally occurring prostate cancer are useful models for molecular ...