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Renaissance of Allostery to Disrupt Protein Kinase Interactions
(Elsevier Science London, 2019-11)
Protein–protein interactions often regulate the activity of protein kinases by allosterically modulating the conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ...
The Catalytic Subunit of cAMP‐Dependent Protein Kinase from Ascaris suum The Cloning and Structure of a Novel Subtype of Protein Kinase A
(1995)
A complete cDNA clone encoding the catalytic subunit of cAMP‐dependent protein kinase of Ascaris suum was constructed from two overlapping partial clones. The encoded sequence of 337 ammo acids is 48 % identical with the ...
Role of the carboxyl terminus on the catalytic activity of protein kinase CK2α subunit
(2002)
Protein kinase CK2 (also known as casein kinase 2) has catalytic (α, α′) and regulatory (β) subunits. The role of carboxyl amino acids in positions from 324 to 328 was studied for Xenopus laevis CK2α. Deletions and mutations ...
Effects of protein kinase and phosphatidylinositol-3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi
(Oxford University Press, 2020)
CK2α/CK1α chimeras are sensitive to regulation by the CK2β subunit
(2008)
The effect of CK2β on the activity of CK2α and other protein kinases that can bind this regulatory subunit is not fully understood. In an attempt to improve our understanding of this effect, chimeras of CK2α and CK1α have ...
The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae
(Portland Press, 2012-09)
PDK1 (phosphoinositide-dependent protein kinase 1) phosphorylates and activates PKA (cAMP-dependent protein kinase) in vitro. Docking of the HM (hydrophobic motif) in the C-terminal tail of the PKA catalytic subunits on ...
A protein kinase screen of Neurospora crassa mutant strains reveals that the SNF1 protein kinase promotes glycogen synthase phosphorylation
(2014)
Glycogen functions as a carbohydrate reserve in a variety of organisms and its metabolism is highly regulated. The activities of glycogen synthase and glycogen phosphorylase, the rate-limiting enzymes of the synthesis and ...