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Role of the Chloride co-transporter NKCC1 in excitability of dentate Gyrus in chorinic epilepsy
(2013)
Granule cells of the dentate gyrus (GCDG) are the
gatekeepers of the tri-synaptic hippocamapal
circuit in part by an intrinsically low cell excitability,
which is pathologically increased in Temporal Lobe
Epilepsy. ...
VGLUTs and glutamate synthesis-focus on DRG neurons and pain
(MDPI, 2015-12)
The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of ...
Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats
(Taylor & Francis, 2015-06)
Postnatal stress alters stress responses for life, with serious consequences on the central nervous system (CNS), involving glutamatergic neurotransmission and development of alcohol voluntary intake. Several drugs of ...
Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion
(Society For Neuroscience, 2010-10)
In the mammalian CNS, glial cells expressing excitatory amino acid transporters (EAATs) tightly regulate extracellular glutamate levels to control neurotransmission and protect neurons from excitotoxic damage. Dysregulated ...
Nkcc1 Inhibition Decrease Altered Excitability Of Dentate Gyrus In Adult Epileptic Conditions
(2014)
Granule cells of the dentate gyrus (GCDG) are the gatekeepers of hippocampal circuit by an intrinsically
low cell excitability, which is pathologically increased in Temporal Lobe Epilepsy. Alterations in balance
between ...