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Beta-lactamases de espectro ampliado (ESBL) produzido por enterobactérias: mecanismo de ação, diagnóstico e controle
(Universidade Federal de Minas GeraisUFMG, 2015-03-16)
The antimicrobial resistance has increased in Brazil and wordwide in the last years. The extended spectrum beta-lactamases (ESBL) is an important mechanism among a great variety of resistance mechanisms. This study is aimed ...
Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru
(MDPI, 2021)
Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment ...
Correlation of phenotypic tests with the presence of the blaZ gene for detection of beta-lactamase
(2017-01-01)
Staphylococcus aureus and Staphylococcus saprophyticus are the most common and most important staphylococcal species associated with urinary tract infections. The objective of the present study was to compare and to evaluate ...
Estudo in silico da diversidade entre enzimas responsáveis pela resistência bacteriana a diferentes classes de antimicrobianos com foco principal em beta-lactamases
(2018)
Bactérias podem se tornar resistentes à ação dos antibióticos por diferentes mecanismos, mas a produção de enzimas inativadoras é considerada o mecanismo mais eficiente e capaz de se disseminar com maior facilidade. Dentre ...
Shaping substrate selectivity in a broad-spectrum metallo-β-lactamase
(American Society for Microbiology, 2018-04)
Metallo-β-lactamases (MBLs) are the major group of carbapenemases produced by bacterial pathogens. The design of MBL inhibitors has been limited by, among other issues, incomplete knowledge about how these enzymes modulate ...
Understanding the Covalent binding of Clavulanate against beta-lactamases (TEM-1 and KPC-2) with QM/ MM methods.
(2017)
β-lactamases are a primary cause of bacterial resistance to β-lactam antibiotics for many important human pathogens
(particularly Gram-negative bacteria) (Hermann, Pradon, Harvey, & Mulholland, 2009). Inhibitors of ...