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Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
(SOC BIOLGIA CHILE, 2008)
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
Inhibition of Nitric Oxide and Tumour Necrosis Factor-alpha Production in Peritoneal Macrophages by Aspergillus nidulans Melanin
(Pharmaceutical Soc Japan, 2013-12-01)
The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the effects of melanin ...
Estratégia de troca entre agentes anti-TNF-alfa não melhora a capacidade funcional em pacientes com artrite reumatoide de longa evolução
(Sociedade Brasileira de Reumatologia, 2012-02-01)
OBJECTIVES: To assess clinical response after switching between anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: This study included 99 patients ...
Effect of Anti-TNF-α on the Development of Offspring and Pregnancy Loss During Pregnancy in Rats
(Universidade Federal do Rio Grande do Sul, 2016)
Estudo da imunogenicidade e segurança da vacina tríplice bacteriana acelular do adulto (dTpa) em crianças e adolescentes com artrite idiopática juvenil (AIJ)
(Universidade Federal de São Paulo (UNIFESP), 2017-05-25)
Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood, accounting for varying degrees of physical disability. Protection of infections through active immunization is ...
The skin tissue is adversely affected by TNF-alpha blockers in patients with chronic inflammatory arthritis: a 5-year prospective analysis
(Faculdade de Medicina / USP, 2013-09-01)
OBJECTIVE: We evaluated the incidence of and the main risk factors associated with cutaneous adverse events in patients with chronic inflammatory arthritis following anti-TNF-α therapy. METHODS: A total of 257 patients ...
Influence of TNF-α blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients
(2012-12-04)
Objectives: To compare the oral prevalence and antimicrobial susceptibility of Candida spp., staphylococci, enterobacteriaceae, and pseudomonas spp.from ankylosing spondylitis (AS) patients receiving conventional and ...
Influence of TNF-α blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients
(2012-12-04)
Objectives: To compare the oral prevalence and antimicrobial susceptibility of Candida spp., staphylococci, enterobacteriaceae, and pseudomonas spp.from ankylosing spondylitis (AS) patients receiving conventional and ...
Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes
(Informa Healthcare, 2011-10-01)
The glycoprotein gp43 is an immunodominant antigen secreted by Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. The present study evaluated whether gp43 can interact with toll-like (TLR2, TLR4) and mannose ...
Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes
(Informa Healthcare, 2011-10-01)
The glycoprotein gp43 is an immunodominant antigen secreted by Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. The present study evaluated whether gp43 can interact with toll-like (TLR2, TLR4) and mannose ...