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Mostrando ítems 11-20 de 24
Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICX - DEPARTAMENTO DE ESTATÍSTICAMED - DEPARTAMENTO DE CLÍNICA MÉDICAUFMG, 2019)
A varfarina apresenta uma ampla variação nos requisitos de dose. Buscamos avaliar a associação dos polimorfismos CYP2C9*2 (rs1799853), CYP2C9*3 (rs1075910) e VKORC1-G1639A (rs9923231) e fatores não genéticos com doses de ...
Variabilidad genética en el factor VII de coagulación, Citocromos P450, γ-Glutamil carboxilasa y el complejo vitamina k epoxido-reductasa y su asociación con la dosis de fármacos antivítaminicos k
(Universidad de Chile, 2019)
INTRODUCCIÓN: En Chile, las enfermedades cardiovasculares son la primera causa de morbimortalidad. Entre los fármacos que se utilizan para su tratamiento se encuentran los antivitamínicos K (AVK), los cuales presentan un ...
Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients
(NATURE PUBLISHING GROUP, 2008)
A dosing algorithm including genetic (VKORC1 and CYP2C9 genotypes) and nongenetic factors (age, weight, therapeutic indication, and cotreatment with amiodarone or simvastatin) explained 51% of the variance in stable weekly ...
Non-genetic factors and polymorphisms in genes CYP2C9 and VKORC1: predictive algorithms for TTR in Brazilian patients on warfarin
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICX - DEPARTAMENTO DE ESTATÍSTICAUFMG, 2019)
Propósito
Este estudo foi desenhado para avaliar a associação de fatores não genéticos e polimorfismos CYP2C9*2 (rs1799853), CYP2C9*3 (rs1075910) e VKORC1-G1639A (rs9923231) com o tempo na faixa terapêutica (TTR) e para ...
Creating and validating a warfarin pharmacogenetic dosing algorithm for colombian patients
Purpose: Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter-and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 ...
Frecuencias alélicas y genotípicas de polimorfismos en los genes cyp2c9, vkorc1 y cyp4f2 en pacientes colombianos anticoagulados con warfarina
(Universidad del RosarioMaestría en Ciencias con Énfasis en Genética HumanaFacultad de medicina, 2015)
The oral anticoagulant warfarin is the most used worldwide, formulated for the treatment and prevention of thrombotic diseases, its narrow therapeutic index and the wide variability between patients make it difficult dosage, ...
A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study
(Frontiers Media, 2020)
Background
Vitamin K antagonists (VKA) are used as prophylaxis for thromboembolic events in patients with cardiovascular diseases. The most common VKA are warfarin and acenocoumarol. These drugs have a narrow therapeutic ...
Análisis farmacogenético retrospectivo de una paciente pediátrica en tratamiento anticoagulante: caso clínico
(Inst Nacional Salud, Colombia, 2021)
We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, ...