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High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
(Nature, 2014-05)
Inhibition of distinct ubiquitin E3 ligases might represent a powerful therapeutic tool. ITCH is a HECT domain-containing E3 ligase that promotes the ubiquitylation and degradation of several proteins, including p73, p63, ...
Structure And Function Of The Yeast Listerin (ltn1) Conserved N-terminal Domain In Binding To Stalled 60s Ribosomal Subunits
(Natl Acad SciencesWashington, 2016)
GPCR receptor phosphorylation and endocytosis are not necessary to switch polarized growth between internal cues during pheromone response in S. cerevisiae
(Taylor & Francis, 2020-08-20)
Chemotactic/chemotropic cells follow accurately the direction of gradients of regulatory molecules. Many G-protein-coupled receptors (GPCR) function as chemoattractant receptors to guide polarized responses. In “a” mating ...
20S Proteasome: Structural study using SAXS.
(Comitê dos Usuários do LNLSCNPEM/LNLSCampinas, 2013-02-26)
The process of intracellular proteolysis (protein degradation) is a regulatory mechanism of cellular homeostasis with the same level of importance as gene expression.The proteasome is a proteolytic complex responsible for ...
The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome
The proteasome is the major non-lysosomal proteolytic machine in cells that, through degradation of ubiquitylated substrates, regulates virtually all cellular functions. Numerous accessory proteins influence the activity ...
An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
The Ubiquitin Specific Protease-19 (USP19) regulates cell cycle progression and is involved in the cellular response to different types of stress, including the unfolded protein response (UPR), hypoxia and muscle atrophy. ...
The Rqc2/tae2 Subunit Of The Ribosome-associated Quality Control (rqc) Complex Marks Ribosome-stalled Nascent Polypeptide Chains For Aggregation
(ELIFE SCIENCES PUBLICATIONS LTDCAMBRIDGE, 2016)
The Rqc2/tae2 Subunit Of The Ribosome-associated Quality Control (rqc) Complex Marks Ribosome-stalled Nascent Polypeptide Chains For Aggregation
(Elife Sciences Publications LtdCambridge, 2016)
20S proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast Saccharomyces cerevisiae: Implications for the degradation of oxidized proteins
(Elsevier Inc.Maryland Heights, 2014-05-09)
Protein S-glutathionylation is a post-translational modification that controls many cellular pathways. Recently, we demonstrated that the α5-subunit of the 20S proteasome is S-glutathionylated in yeast cells grown to the ...
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
(Nature Publishing Group, 2015-02)
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. ...