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Genotyping of resistance to thyroid hormone in South American population. Identification of seven novel missense mutations in the human thyroid hormone receptor β gene
(2009)
Thyroid Hormone Receptor β (THRB) defects, typically transmitted as autosomal dominant traits, cause Resistance to Thyroid Hormone (RTH). We analyzed the THRB gene in thirteen South American patients with clinical evidence ...
Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
(Wiley Blackwell Publishing, Inc, 2011-03)
Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential ...
A novel 1297–1304delGCCTGCCA mutation in the exon 10 of the thyroid hormone receptor β gene causes resistance to thyroid hormone
(Springer, 2012-12-01)
Introduction: Resistance to the thyroid hormone (RTH) is an inherited syndrome of reduced tissue responsiveness to hormonal action caused by mutations located in the ligand-binding domain and adjacent hinge region of the ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SPRINGER, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SpringerHeidelberg, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
Nanostructured sensors containing immobilized nuclear receptors for thyroid hormone detection
(American Scientific Publishers - ASPValencia, 2014-05)
Thyroid hormone receptors (TRs) are members of the nuclear receptors (NRs) superfamily, being encoded by two genes: TRα and TRβ. In this paper, the ligand-binding domain (LBD) of the TRβ1 isoform was immobilized on the ...
The importance of hormone receptor analysis in osteosarcoma cells growth submitted to treatment with estrogen in association with thyroid hormone
(JOHN WILEY & SONS LTD, 2008)
Bone tumor incidence in women peaks at age 50-60, coinciding with the menopause. That estrogen (E2) and triiodothyronine (T3) interact in bone metabolism has been well established. However, few data on the action of these ...
Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats
(2010-10-01)
Excessive and chronic alcohol intake leads to a lower hepatic vitamin A status by interfering with vitamin A metabolism. Dietary provitamin A carotenoids can be converted into vitamin A mainly by carotenoid 15,15′-monooxygenase ...