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Mostrando ítems 11-20 de 58
Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones
(Molecular Diversity Preservation International, 2013-05)
New hetaryl- and alkylidenerhodanine derivatives 3a–d, 3e, and 4a–d were prepared from heterocyclic aldehydes 1a–d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a–d and 3e with piperidine or morpholine ...
Desing and synthesis of potent anti-trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAUFMG, 2017)
A doença de Chagas, causada pelo protozoário cinetoplastídeo Trypanosoma cruzi, continua sendo uma importante causa de doença e morte prematura e estima-se que 6 milhões a 7 milhões de pessoas estejam infectadas em todo o ...
1,1 '-Carbonyldiimidazole mediates the synthesis of N-substituted imidazole derivatives from Morita-Baylis-Hillman adducts
(Pergamon-elsevier Science LtdOxfordInglaterra, 2014)
Planejamento estrutural, síntese e avaliação das propriedades farmacológicas de inéditas tiazolil-hidrazonas derivadas da ftalimida e da isatina
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Farmaceuticas, 2017)
Síntese de heterociclos: 2-alquil/arilcalcogeno-n-(4-aril-1,3-tiazol-2-il)acetamidas e (s)-n-(1-(3-aril-1,2,4-oxadiazol-5-il)alquil)-2-(calcogenofenil) acetamidas derivados de organocalcogênios
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2015-03-27)
In the present work, a series of 2-alkyl/arylchalcogenide-N-(4-aryl-1,3-thiazol-2-yl)acetamide was prepared via addition of aryl or alkyl chalcogenides. This methodology allowed the preparation of new derivatives of ...
Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity
(American Chemical Society, 2014-04)
Chagas disease, caused by Trypanosoma cruzi parasite, was described thousands of years ago. Currently, it affects millions of people, mostly in Latin America, and there are not suitable drugs for treating it. As an attempt ...
Síntese e avaliação das atividades antioxidante e citotóxica de análogos da curcumina e heterociclos tiazólicos
(Universidade Federal de Minas GeraisUFMG, 2014-02-23)
Substances with antioxidant properties have been extensively studied because of their therapeutic potential in the treatment and/or prevention of numerous types of diseases, including cancer. Curcumin is one of the most ...
Cromóforos rígidos derivados de tiazol o [5, 4-d] tiazol: cristais líquidos e sais orgânicos fotocromáticos
(Universidade Federal de PernambucoufpeBrasilPrograma de Pos Graduacao em Quimica, 2016)