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Mostrando ítems 11-20 de 188
Inhibition of L-Type Ca 2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons
(Society for Neuroscience, 2017-03)
Loss of dopaminergic (DA) neurons leads to Parkinson’s disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood. We demonstrate that TRPC1 regulates the L-type Ca2 channel that ...
Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3
(Nature Publishing Group, 2017-02)
In previous work we reported that ApoeKO mice transplanted with bone marrow cells deficient in the Transient Receptor Potential Canonical 3 (TRPC3) channel have reduced necrosis and number of apoptotic macrophages in ...
Angiotensin-II-evoked Ca2+ entry in murine cardiac gibroblasts does not depend on TRPC channels
(MDPI, 2020)
Abstract: TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and ...
TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo
(Wiley-liss, Div John Wiley & Sons Inc, 2017-06)
Following brain injury astrocytes change into a reactive state, proliferate and grow into the site of lesion, a process called astrogliosis, initiated and regulated by changes in cytoplasmic Ca2+. Transient receptor potential ...
A background Ca 2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling
(Oxford University Press, 2015-09)
Aims: Pathological cardiac hypertrophy is a major predictor for the development of cardiac diseases. It is associated with chronic neurohumoral stimulation and with altered cardiac Ca2+ signalling in cardiomyocytes. TRPC ...
Murine cardiac growth, TRPC channels, and cGMP kinase I
(Springer, 2015)
RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways
(Nature Research, 2020)
Abstract: The seven-member transient receptor potential canonical genes (TRPC1-7) encode cation channels
linked to several human diseases. There is little understanding of the participation of each TRPC in each
pathology, ...
TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
(Nature Publishing Group, 2016-11)
Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation to mechanical load and maladaptive remodeling of the heart. This is ...
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages
(American Physiological Society, 2014-09)
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe-/- mice with ...
Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries
(Public Library of Science, 2014-10)
Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization ...