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Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture
Whole exome sequencing (WES) is a widely used strategy for detection of protein coding and splicing variants associated with inherited diseases. Many studies have shown that the strategy has been broad and proficient due ...
Mapping causal mutations by exome sequencing in a wheat TILLING population: a tall mutant case study
(Springer Heidelberg, 2018-04)
Forward genetic screens of induced mutant plant populations are powerful tools to identify genes underlying phenotypes of interest. Using traditional techniques, mapping causative mutations from forward screens is a lengthy, ...
Mining sequences in activities for time use analysis
(IOS Press, 2020)
By providing a complete record of time use for a given population, time use studies enable investigators to test various hypotheses concerning that behavior. However, the large number and variety of activity combinations ...
Phylogenomic evidence for a recent and rapid radiation of lizards in the Patagonian Liolaemus fitzingerii species group
(Academic Press Inc Elsevier Science, 2018-08)
Rapid evolutionary radiations are difficult to resolve because divergence events are nearly synchronous and gene flow among nascent species can be high, resulting in a phylogenetic “bush”. Large datasets composed of sequence ...
Translocation capture sequencing: A method for high throughput mapping of chromosomal rearrangements
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are involved in producing leukemias, lymphomas and sarcomas. Translocations ...
Improving resource productivity at a crop sequence level
(Elsevier Science, 2019-04-01)
The challenge to increase agricultural production with a minimum environmental impact requires to reach the maximum efficiency in the capture and use of resources such as photosynthetically active radiation (PAR), water, ...