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Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model
(Lawrence Erlbaum Associação Inc, 2004-01-01)
The eventual chemopreventive effect of squalene (SQ), a triterpene present in olive oil, was evaluated when administered to Wistar rats during a period comprising the initiation and selection/promotion of the resistant ...
Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model
(Lawrence Erlbaum Associação Inc, 2004-01-01)
The eventual chemopreventive effect of squalene (SQ), a triterpene present in olive oil, was evaluated when administered to Wistar rats during a period comprising the initiation and selection/promotion of the resistant ...
Bulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy
It has been ten years since the identification of NTCP as the cell surface receptor for HBV and HDV entry into hepatocytes. The search for molecules interfering with the binding of NTCP and HBV/HDV led to design bulevirtide ...
Structure activity relationship, acute toxicity and cytotoxicity of antimycobacterial neolignan analogues
(WILEY-BLACKWELLEstados Unidos, 2011)
Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model
(Lawrence Erlbaum Associação Inc, 2014)
Estabelecimento de metodologia de isolamento e cultivo primário de hepatócitos bovinos para estudos do efeito modulador da saliva do carrapato Rhipicephalus microplus sobre expressão de genes relacionados à imunidade inata
(Universidade Federal de Juiz de Fora (UFJF)BrasilICB – Instituto de Ciências BiológicasPrograma de Pós-graduação em Ciências Biológicas: Imunologia e Doenças Infecto-Parasitárias/Genética e BiotecnologiaUFJF, 2019)
Fructose and NAFLD: metabolic implications and models of induction in rats
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2011)
PURPOSE: The increase in fructose consumption is paralleled by a higher incidence of obesity worldwide. This monosaccharide is linked to metabolic syndrome, being associated with hypertriglyceridemia, hypertension, insulin ...
Physiological concentrations of unconjugated bilirubin prevent oxidative stress‑induced hepatocanalicular dysfunction and cholestasis
(Springer, 2014-11)
Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most ...
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, BcI-2 and NF-kappa B pathways
(WILEY-LISS, 2008)
During rat hepatocarcinogenesis preneoplastic lesions (PNL) emerge which may persist (pPNL) and be sites of progress to cancer or suffer remodeling (rPNL) tending to disappear. Cellular and molecular mechanisms involved ...