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Mostrando ítems 11-20 de 198
O papel do PPARα na atividade voluntária de camundongos
(Universidade Federal de São Paulo, 2021-11-29)
Objetivo: Avaliar a participação do fator de transcrição PPARα na atividade voluntária e em aspectos metabólicos de camundongos fêmeas, em estado alimentado e em jejum, analisando a frequência de utilização da roda voluntária ...
Rosa mosqueta oil prevents oxidative stress and inflammation through the upregulation of PPAR-α and NRF2 in C57BL/6J mice fed a high-fat diet
(American Society for Nutrition, 2017)
© 2017 American Society for Nutrition. Background: Rosa mosqueta (RM) oil is characterized by high concentrations of antioxidants and α-linolenic acid (ALA; 18:3n-3). We have previously demonstrated in male C57BL/6J mice ...
Glial modulation by N-acylethanolamides in brain injury and neurodegeneration
(Frontiers Media S.A., 2016-04)
Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their ...
Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
(Elsevier Ireland, 2017-07)
Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) ...
The offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease
(Elsevier Ireland, 2020-07)
Maternal obesity programs liver derangements similar to those of NAFLD. Our main goal was to evaluate whether these liver anomalies were related to aberrant PPARα function. Obesity was induced in female Albino-Wistar rats ...
Megalin/LRP2 Expression is induced by peroxisome proliferator-activated receptor-alpha and –gamma: Physiopathological implications for kidney function
(2009)
BACKGROUND: Megalin is a large endocytic receptor with relevant functions during development and adult life. It is expressed at the apical surface of several epithelial cell types, including proximal tubule cells (PTCs) ...
PPARalpha agonists regulate lipid metabolism and nitric oxide production and prevents placental overgrowth in tern in placentas from diabetic rats
(BioScientifica, 2011-06)
Maternal diabetes impairs fetoplacental metabolism and growth. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor capable of regulating lipid metabolism and inflammatory pathways. In this study, we ...
Peroxisome proliferator-activated receptor α activation regulates lipid metabolism in the feto-placental unit from diabetic rats
(BioScientifica, 2008-07)
Maternal diabetes promotes an overaccumulation of lipids in the feto-placental unit and impairs feto-placental development and growth. Here, we investigated the role played by the nuclear receptor peroxisome proliferator-activated ...
Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect
(American Chemical Society, 2019-07-03)
Dual peroxisome proliferator-activated receptor-α/γ (PPARα/γ) agonists regulate both lipid and glucose homeostasis under different metabolic conditions and can exert anti-inflammatory activity. We investigated the potential ...
Aceite de linaza como fuente de ácidos grasos poliinsaturados sobre expresión del Gen PPARα y perfil lipídico en ratas obesas
(Universidad Nacional Agraria La Molina, 2018)
El consumo de aceite linaza que es fuente de ácidos grasos poliinsaturados n-3 se ha asociado con la mejora de perfil lipídico y expresión génica de factores de transcripción en modelos animales; sin embargo, es poco lo ...