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Quercetin 3, 7, 3´, 4´-Tetrasulphate from Flaveria bidentis Inhibits the Plasminogen Activator Inhibitor-1 but not the Tissue-Type Plasminogen Activator Expression in Human Normal Fibroblasts
(International Scholars Journals, 2015-06)
Sulphated flavonoids quercetin 3, 7, 3´, 4´-tetrasulphated (QTS) and quercetin 3-acetyl-7, 3´, 4´-trisulphate (ATS), obtained from Flaveria bidentis have demonstrated some antithrombotic properties. We analyzed whether ...
Purification, crystallization and preliminary crystallographic study of a Kunitz-type trypsin inhibitor from Delonix regia seeds
(Munksgaard Int Publ LtdCopenhagenDinamarca, 1999)
Reduction of Steroid-Induced Intraocular Pressure Elevation in Sheep by Tissue Plasminogen Activator
(Association For Research In Vision And Ophthalmology, 2013-12)
PURPOSE. To investigate whether tissue plasminogen activator (tPA) can prevent and/or reverse steroid-induced IOP elevation in an ovine model.
METHODS. Three animal groups were subjected to bilateral steroid-induced IOP ...
Tyssue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression
(Springer, 2006-12)
Purpose: To investigate whether the level of plasminogen activator (PA) activity assayed in gastrointestinal carcinomas and the "morphologically normal tissues" adjacent to them is associated with the degree of tumor ...
Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study
(Associação Brasileira de Divulgação Científica, 2008)
We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 ...
Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy
(LIPPINCOTT WILLIAMS & WILKINS, 2003)
Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on ...
Heparin modulation of human plasma kallikrein on different substrates and inhibitors
(Walter de Gruyter & Co, 2006-08-01)
The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures. Human plasma kallikrein ( huPK) is a proteolytic enzyme involved in intrinsic blood ...
Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease model
(Elsevier Ireland, 2009-09)
OBJECTIVE: To evaluate the effect of losartan-an angiotensin II type 1 receptor (AT1R) antagonist- and telmisartan-an AT1R blocker with insulin-sensitizing properties-, on the hepatic expression of plasminogen activator ...
SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
(2012)
Transforming growth factor-β1 (TGF-β1) stimulates the extracellular matrix degrading proteases expression and cell migration in order to enhance cancer cells malignancy. In the present study, we analysed the role of ...