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Mostrando ítems 11-20 de 281
Release of Acetylcholinesterase (AChE) from β-Amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
(2008)
The major protein constituent of amyloid deposits in Alzheimer's disease (AD) is the amyloid-beta-peptide (Abeta). Amyloid deposits contain "chaperone molecules" which play critical roles in amyloid formation and toxicity. ...
Circadian and sleep dysfunction in Alzheimer's disease
(Elsevier Ireland Ltd, 2020)
Expression of scavenger receptors in glial cells - Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005)
Astrocytes and microglia associate to amyloid plaques, a pathological hallmark of Alzheimer disease. Microglia are activated by and can phagocytose beta-amyloid ( A beta). Scavenger receptors ( SRs) are among the receptors ...
Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons
(2012)
Two major lesions are pathological hallmarks in Alzheimer's disease (AD): the presence of neurofibrillary tangles formed by intracellular aggregates of the hyperphosphorylated form of the cytoskeletal tau protein, and of ...
Octodon degus, toward its consolidation as a natural model of Alzheimer`s disease
(2018)
Alzheimer`s disease (AD) is the leading cause of age-related dementia worldwide. No therapy is currently available to stops or reverses the progression of
AD. Because of the disappointing results obtained in different ...
Identificação e caracterização de proteína β-amiloide em camundongos bitransgênicos para Alzheimer através de espectroscopia Raman: primeiro passo para o estabelecimento de uma plataforma de espectroscopia intraocular para fins de diagnóstico precoce
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em Inovação Tecnológica e BiofarmacêuticaUFMG, 2020-11-05)
In the last decades, there has been a significant increase in the life expectancy of the world population. This increase in years of life brought a greater incidence of diseases related to aging, among them, as age-dependent ...