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Comparative time-course study of aminoacyl- and dipeptidyl-resin hydrolysis
(Sociedade Brasileira de Química, 1997-01-01)
The classic hydrolysis procedure for quantification of resin-bound aminoacyl and peptidyl groups with 12 N HCl: propionic acid was reevaluated by studying the influence of the nature of the resin and the resin-bound group. ...
Síntese de peptídeos em fase sólida: reavaliação do uso do ácido trifluorometanosulfônico na etapa de clivagem peptídica da resina
(Universidade Federal de São Paulo (UNIFESP), 2017-04-28)
The main objective of the present work was to reavaluate the strategy of the use of trifluoromethanesulfonic acid (TFMSA) in the step of final cleavage of peptides from the support resin. The main reason for investing in ...
p-Methoxyphenol: A potent and effective scavenger for solid-phase peptide synthesis
During the final step of t-Boc/Bzl, solid-phase peptide synthesis (SPPS)-protecting groups from amino acids (aa) side chains must be removed from the target peptides during cleavage from the solid support. These reaction ...
p-Methoxyphenol: A potent and effective scavenger for solid-phase peptide synthesis
(2020)
During the final step of t-Boc/Bzl, solid-phase peptide synthesis (SPPS)-protecting groups from amino acids (aa) side chains must be removed from the target peptides during cleavage from the solid support. These reaction ...
Síntese em fase sólida, caracterização e estudo conformacional da δ melantropina e da δ melantropina oxidada
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2005-03-12)
The δ melanotropin is a peptide with sequence H-Ser-Met-Glu-Val-Arg-Gli-Trp-OH. The synthesis of this peptide was carried out by the methodology in solid phase, being the sequence synthesized on a polymeric support by means ...
Angiotensin processing is partially carried out by carboxypeptidases in the rat mesenteric arterial bed perfusate
(ELSEVIER SCIENCE BV, 2008)
Here we investigated the possible association between the carboxypeptidase A (CPA)-like activity of the rat mesenteric arterial bed (MAB) perfusate and the ability of this fluid of forming angiotensin (Ang) 1-9 and Ang 1-7 ...
Quimeras peptídicas: una alternativa sintética para potenciar la actividad antimicrobiana de péptidos
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2022)
La emergencia provocada por la resistencia microbiana a los medicamentos disponibles actualmente ha motivado el desarrollo de agente terapéuticos que superen esta limitación. Los péptidos antimicrobianos (PAMs) son una ...
Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity
(Elsevier B.V., 2015-01-01)
KLK7 substrate specificity was evaluated by families of fluorescence resonance energy transfer (FRET) peptides derived from Abz-KLFSSK-Q-EDDnp (Abz = ortho-aminobenzoic acid and Q-EDDnp = glutaminyl-N-[2,4-dinitrophenyl] ...
Evaluación in-vitro de péptidos sintéticos diseñados a partir de la Conantoquina G (Con-G) con interacción sobre la subunidad GluN2B del receptor de Glutamato tipo N-metil-D-aspartato (NMDAr) y su posible efecto sobre las vías de señalización involucradas en procesos de excitotoxicidad por calcio
(Universidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BioquímicaDepartamento de QuímicaFacultad de CienciasBogotáUniversidad Nacional de Colombia - Sede Bogotá, 2020-09-05)
Los receptores activados por el aminoácido glutamato de tipo N-metil-D-aspartato (NMDARs) son canales iónicos a través de los cuales fluyen iones calcio (Ca2+) hacia la neurona postsináptica, además de permear iones sodio ...