Buscar
Mostrando ítems 11-20 de 443
Pharmacological Evaluation and Preliminary Pharmacokinetics Studies of a New Diclofenac Prodrug without Gastric Ulceration Effect
(Mdpi Ag, 2012-11-01)
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular events. Among the molecular modifications strategies, the prodrug ...
Synthesis and thermal study of the prodrug of oxamniquine
(Springer, 2006-02-01)
Oxamniquine polymeric prodrug with potential antischistosomal activity was prepared using dextran T-70 as a carrier, which was analysed by (HNMR)-H-1, C-13 NMR and IR spectroscopy. The formation of the oxamniquine salt was ...
Synthesis and thermal study of the prodrug of oxamniquine
(Springer, 2006-02-01)
Oxamniquine polymeric prodrug with potential antischistosomal activity was prepared using dextran T-70 as a carrier, which was analysed by (HNMR)-H-1, C-13 NMR and IR spectroscopy. The formation of the oxamniquine salt was ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(2013-01-01)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
Evaluation and synthesis of AZT prodrugs with optimized chemical stabilities: Experimental and theoretical analyses
(Royal Society of Chemistry, 2016-01)
The design of prodrugs of nucleoside reverse transcriptase inhibitors (NRTIs) constitutes a promising strategy to overcome several suboptimal pharmacotherapeutic properties of these kinds of drugs, among which zidovudine ...
Latenciação e formas avançadas de transporte de fármacos
(Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2005-06-01)
O processo de modificação molecular denominado latenciação é revisto, apresentando formas avançadas no transporte de fármacos, utilizando macromoléculas como transportadores e sistemas de liberação sítio-específica como: ...
Atividade antiedema do pró-fármaco polimérico PDC-70 derivado do diclofenaco
(2002-12-01)
The PDC-70 polymeric prodrug derived from the diclofenac has shown antiedema activity when administered through intramuscular route in rats. Besides that it has produced superior activity when compared to the diclofenac ...
Atividade antiedema do pró-fármaco polimérico PDC-70 derivado do diclofenaco
(2002-12-01)
The PDC-70 polymeric prodrug derived from the diclofenac has shown antiedema activity when administered through intramuscular route in rats. Besides that it has produced superior activity when compared to the diclofenac ...