Synthesis and thermal study of the prodrug of oxamniquine

Artigo

Fecha

2006-02-01

Registro en:

Journal of Thermal Analysis and Calorimetry. Dordrecht: Springer, v. 83, n. 2, p. 277-281, 2006.

1388-6150

http://hdl.handle.net/11449/35481

10.1007/s10973-005-6875-5

WOS:000235902500004

7471310113999140

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3907412

Autor

Universidade Estadual Paulista (Unesp)

Fundação Oswaldo Cruz

Universidade Federal de São Carlos (UFSCar)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

Oxamniquine polymeric prodrug with potential antischistosomal activity was prepared using dextran T-70 as a carrier, which was analysed by (HNMR)-H-1, C-13 NMR and IR spectroscopy. The formation of the oxamniquine salt was confirmed by thermogravimetric analysis (TG) and differential scanning calorimetry (DSC) which showed a different thermal behaviour when compared to the physical mixture.

Materias

DSC

oxamniquine

prodrug

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