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Nutritional factors and aging in demyelinating diseases
(Springer Verlag Berlín, 2014-01)
Demyelination is a pathological process characterized by the loss of myelin around axons. In the central nervous system, oligodendroglial damage and demyelination are common pathological features characterizing white matter ...
Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
(Elsevier, 2014-02)
Galectin-3 (Gal-3) is a β-galactoside-binding lectin that plays an important role in inflammatory and neurodegenerative diseases. Cuprizone (CPZ)-induced demyelination is characterized by the loss of mature oligodendrocytes ...
Oligodendrocyte differentiation and signaling after transferrin internalization: a mechanism of action
(Elsevier, 2013-10)
Oligodendrocytes are the cells producing the myelin membrane around the axons in the central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte differentiation, the underlying mechanisms are ...
Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination
(Academic Press Inc Elsevier Science, 2008-08)
In the present work we analyzed the capacity of thyroid hormones (THs) to improve remyelination using a rat model of cuprizone-induced demyelination previously described in our laboratories. Twenty one day old Wistar rats ...
Transferrin Enhances Microglial Phagocytic Capacity
(Humana Press, 2019-02)
Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells. This molecule has been shown to accelerate the process of ...
TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques
(Nature Publishing Group, 2019)
Oligodendrocyte precursor cells (OPCs) differentiate during postnatal development into myelin-forming oligodendrocytes, in a process distinguished by substantial changes in morphology and the onset of myelin gene expression. ...
Transferrin and thyroid hormone converge in the control of myelinogenesis
(Academic Press Inc Elsevier Science, 2015-03)
Myelination is a concerted mechanism tightly regulated in the brain. Although several factors are known to participate during this process, the complete sequence of events is far from being fully elucidated. Separate effects ...
Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro
(Wiley, 2016-07)
Thyroid hormones (THs) and transferrin (Tf) are factors capable of favoring myelination due to their positive effects on oligodendroglial cell (OLG) differentiation. The first notion of a combined effect of apotransferrin ...
Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action
(Humana Press, 2019-10)
Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-KDa ...
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
(Nature Publishing Group, 2011-11)
Galectins control critical pathophysiological processes, including the progression and resolution of central nervous system (CNS) inflammation. In spite of considerable progress in dissecting their role within lymphoid ...