Buscar
Mostrando ítems 11-20 de 21
Efficient method for targeted gene disruption by homologous recombination in Mycobacterium avium subspecie paratuberculosis
(Elsevier Science, 2020-04)
Targeted gene disruption by homologous recombination, has been widely used in mycobacterium species to understand the genetic basis of virulence and persistence in the host and to develop efficacious potential live vaccines. ...
Resposta induzida pelo Mycobacterium tuberculosis com interrupção no operon mce1 e os lipídios da parede celular: uma análise para identificação de biomarcadores
(Instituto Gonçalo Moniz, 2019)
INTRODUÇÃO. Mycobacterium tuberculosis (M. tuberculosis) apresenta características peculiares quando comparado a outros patógenos. A interrupção no operon mce1 (mce1) do M. tuberculosis, um putativo transportador de ...
Metabolic profile of mycobacterium smegmatis reveals Mce4 proteins are relevant for cell wall lipid homeostasis
(2016)
Introduction The Mce proteins are encoded in a variable number of operons (from one to eight) in all Mycobacterium species. A role in the transport of host and mycobacterial lipids has been demonstrated for some Mce proteins ...
Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
(Journal of Infection in Developing Countries, 2016-08)
Mycobacterium bovis (Mb), the causative agent of bovine tuberculosis (bTB), infects cattle and other animals, including humans. In this study we found that a M. bovis knockout strain in phoP and mce2 operons protected ...
Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis
(Churchill Livingstone, 2015-03)
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than ...
Alterações na homeostase lipídica em macrófagos estimulados por lipídios do mycobacterium tuberculosis
(2021)
INTRODUÇÃO: O Mycobacterium tuberculosis (Mtb), agente causador da Tuberculose (TB), é capaz de modular metabolicamente o macrófago, induzir a formação de corpos lipídicos e persistir em uma infecção latente. Alterações ...
Efficient method for targeted gene disruption by homologous recombination in Mycobacterium avium subspecie paratuberculosis
(Elsevier, 2020-09)
Targeted gene disruption by homologous recombination, has been widely used in mycobacterium species to understand the genetic basis of virulence and persistence in the host and to develop efficacious potential live vaccines. ...