info:eu-repo/semantics/article
Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Fecha
2016-08Registro en:
Garcia, Elizabeth Andrea; Bianco, María Verónica; Blanco, Federico Carlos; Bigi, Fabiana; Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis; Journal of Infection in Developing Countries; Journal of Infection in Developing Countries; 10; 8; 8-2016; 892-894
2036-6590
CONICET Digital
CONICET
Autor
Garcia, Elizabeth Andrea
Bianco, María Verónica
Blanco, Federico Carlos
Bigi, Fabiana
Resumen
Mycobacterium bovis (Mb), the causative agent of bovine tuberculosis (bTB), infects cattle and other animals, including humans. In this study we found that a M. bovis knockout strain in phoP and mce2 operons protected C57BL/6 mice against virulent M. bovis challenge. The double mutant was significantly more attenuated than the parental M. bovis Δmce2 strain in immunodeficient mice.