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Mostrando ítems 11-20 de 34
Suicide plus immune gene therapy prevents post-surgical local relapse and increases overall survival in an aggressive mouse melanoma setting
(Elsevier Science, 2014-09)
In an aggressive B16-F10 murine melanoma model, we evaluated the effectiveness and antitumor mechanisms triggered by a surgery adjuvant treatment that combined a local suicide gene therapy (SG) with a subcutaneous genetic ...
Combination of suicide and cytokine gene therapies as surgery adjuvant for canine mammary carcinoma
(MDPI, 2018-09)
The incidence of canine mammary carcinoma varies with age, breed, and spay status, being among the main tumors appearing in intact female dogs. Thirty-six canine mammary carcinoma patients received injections of canine ...
Cytokine-enhanced vaccine and suicide gene therapy as surgery adjuvant treatments for spontaneous canine melanoma: 9 years of follow-up
(Nature Publishing Group, 2012-12)
We present here the updated results after 9 years of the beginning of a trial on canine patients with malignant melanoma. This surgery adjuvant approach combined local suicide gene therapy with a subcutaneous vaccine ...
Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma
(Nature Publishing Group, 2019-03)
After 6 years of follow-up treating 364 canine melanoma patients, we present here results about the proof-of-concept, safety, and efficacy of a new surgery adjuvant combined gene therapy. The adjuvant treatment (AT) group ...
Síntesis de un lípido catiónico derivado de un aminoácido básico y su caracterización química y biológica para la transferencia de genes
(Universidad Autónoma Metropolitana (México). Unidad Azcapotzalco. División de Ciencias Básicas e Ingeniería., 2015)
La terapia génica es una estrategia terapéutica basada en la modificación del repertorio genético de las células mediante la administración de ácidos nucleicos. La principal limitante de su aplicación in vivo es la dificultad ...
Herpes simplex virus thymidine kinase/ganciclovir system in multicellular tumor spheroids
(Nature Publishing Group, 2004)
Transfección genética in vivo en presencia de fármacos que modifican la lipofección
(23/04/2012)
RESUMEN: La terapia génica se define como el conjunto de metodologías que permiten llevar secuencias de DNA o de RNA al interior de células específicas, con el objetivo de modificar el curso de una enfermedad. La terapia ...
Enhancement of nucleic acid delivery to hard-to-transfect human colorectal cancer cells by magnetofection at laminin coated substrates and promotion of the endosomal/lysosomal escape
(Royal Society of Chemistry, 2015)
Despite a great diversity of nanomaterials, such as cationic lipid, polymers or inorganic nanoparticles, has been developed in order to carry nucleic acids across plasma membrane, these methodologies have still insufficient ...
Estudio in vitro del potencial de la terapia génica con IFN-beta como tratamiento para el melanoma: Efecto bystander, inhibición de la migración celular y potenciación con bortezomibIn vitro study of the potential of interferon-beta gene therapy for treating melanoma: Bystander effect, inhibition of cell migration and enhancement with bortezomib
(2014-04-21)
El melanoma es un cáncer maligno y altamente metastásico. Siendo el interferón-alfa humano recombinante (rhIFNa) un tratamiento aprobado para el melanoma, se propone la administración del gen del IFNa/B como estrategia ...
Induction of Indoleamine 2,3-Dioxygenase by Gene Delivery in Allogeneic Islets Prolongs Allograft Survival
(WILEY-BLACKWELL, 2010)
Indoleamine 2,3-dioxygenase (IDO), an enzyme that plays a critical role in fetomaternal tolerance, exerts immunoregulatory functions suppressing T-cell responses. The aims of this study were to promote IDO expression in ...