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Atividade antitumoral de inibidores de Histona Desacetilase como estratégia terapêutica contra o câncer cervical humano associado ao Papilomavírus Humano (HPV)
(Universidade Estadual Paulista (Unesp), 2021-12-16)
O câncer de colo de útero é o quarto tipo mais comum de câncer entre as mulheres. Sua principal causa é a infecção persistente pelo vírus Papilomavírus Humano (HPV) de alto risco, como o tipo 16 e o 18. As proteínas E6 e ...
Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives
(2020-05-08)
Evidence has emerged implicating epigenetic alterations in inflammatory breast cancer (IBC) origin and progression. IBC is a rare and rapidly progressing disease, considered the most aggressive type of breast cancer (BC). ...
Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos
(CSIRO Publishing, 2010-01-01)
Trichostatin A (TSA) induces histone hyperacetylation by inhibiting histone deacetylases and consequently increasing gene expression. The hypothesis was that TSA supplementation during the in vitro culture (IVC) of bovine ...
Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos
(CSIRO Publishing, 2010-01-01)
Trichostatin A (TSA) induces histone hyperacetylation by inhibiting histone deacetylases and consequently increasing gene expression. The hypothesis was that TSA supplementation during the in vitro culture (IVC) of bovine ...
Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus
(2021-01-28)
The role of epigenetic modifications on the carcinogenesis process has received a lot of attention in the last years. Among those, histone acetylation is a process regulated by histone deacetylases (HDAC) and histone ...
Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A
(Springer, 2014-07-01)
Gastric cancer is still the second leading cause of cancer-related death worldwide, even though its incidence and mortality have declined over the recent few decades. Epigenetic control using histone deacetylase inhibitors, ...
Short- and long-term effects of nicotine and the histone deacetylase inhibitor phenylbutyrate on novel object recognition in zebrafish
(Springer, 2017-03)
Rationale: Zebrafish have a sophisticated color- and shape-sensitive visual system, so we examined color cue-based novel object recognition in zebrafish. We evaluated preference in the absence or presence of drugs that ...
Targeting schistosome histone modifying enzymes for drug development
(Bentham Science Publishers, 2015)