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Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice
(Elsevier, 2015)
Background: Pain is one of the most common problems in clinical medicine. There is considerable
evidence that pharmacologic approaches are the most widely used therapeutic options to ameliorate
persistent or chronic pain. ...
Única dosis de gabapentin preoperatorio para analgesia postoperatoria: revisión de literatura
(Universidad del RosarioEspecialización en Anestesiología HOKFacultad de Medicina, 2012)
Introduction Postoperative pain is a challenge for all anesthesiologist, in recent years it has been proposed the Gabapentin preoperative as a good option without side effects.
Methods We conducted a systematic review ...
Simple and rapid hplc-uv methods for gabapentin quantification in human plasma and urine: Applicability in pharmacokinetics and drug monitoring
(2021-01-01)
Aim: We aimed to develop methods to determine gabapentin (GAB) in biological samples using high-performance liquid chromatography (HPLC) with application in pharmacokinetics and therapeutic drug monitoring. Methods: Simple, ...
Antinociceptive Synergism of Gabapentin and Nortriptyline in Mice with Partial Sciatic Nerve Ligation
(Karger, 2015)
Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an ...
The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Aim: This study evaluates the contribution of inhibitory pain pathways that descend to the spinal cord through the dorsolateral funiculus (DLF) on the effect of intrathecal gabapentin against spinal nerve ligation (SNL)-induced ...
Gabapentin-responsive idiopathic stabbing headache
(Blackwell Publishing LtdOxfordInglaterra, 2004)
Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain
(Nordic Association for the Publication of BCPT, 2016)
Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and ...
Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury.
(2009)
"In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allodynic and
anti-hyperalgesic effects of these drugs, administered either separately or in combination, were determined
using ...
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats
(Elsevier B.V., 2018-05-01)
Purpose: We investigated the influence of diabetes mellitus (DM), glycemic control with insulin, cimetidine (Oct2 inhibitor) and metformin (Oct2 substrate) on the kinetic disposition of GAB in rats. Main methods: Male ...
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice
(Academic Press Inc Elsevier Science, 2010-02)
We previously reported that administration of a single dose of gabapentin (GBP) immediately after training improves memory of mice in an inhibitory avoidance task (IA), whereas GBP administered repeatedly for 7 days impairs ...