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Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall
(2016)
Background:
Diuretics are current antihypertensive drugs since they reduce blood pressure and cardiovascular risk. Increased vascular tone is modulated in a relevant way by the RhoA/Rho-kinase (ROCK) pathway, by acting on ...
Involvement of endothelins in deoxycorticosterone acetate–salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus
(Wiley, 2015-06)
What is the central question of this study? Does ex vivo administration of endothelin-1 and endothelin-3 regulate noradrenergic transmission in the posterior hypothalamus of deoxycorticosterone acetate–salt hypertensive ...
Lifetime Overproduction of Circulating Angiotensin-(1-7) Attenuates Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Dysfunction and Remodeling
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
We evaluated the development of arterial hypertension, cardiac function, and collagen deposition, as well as the level of components of the renin-angiotensin system in the heart of transgenic rats that overexpress an ...
Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor
(Karger, 2001-12)
Salt appetite, a conditioning factor for hypertension and cardiovascular diseases, is produced when high doses of mineralocorticoids are given to experimental animals. A commonly used procedure to identify neuronal activation ...
Impaired Vasodilator Activity in Deoxycorticosterone Acetate-Salt Hypertension Is Associated With Increased Protein O-GlcNAcylation
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Hyperglycemia, which increases O-linked beta-N-acetylglucosamine (O-GlcNAc) proteins, leads to changes in vascular reactivity. Because vascular dysfunction is a key feature of arterial hypertension, we hypothesized that ...
O-GlcNAcylation Contributes to Augmented Vascular Reactivity Induced by Endothelin 1
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
O-GlcNAcylation augments vascular contractile responses, and O-GlcNAc-proteins are increased in the vasculature of deoxycorticosterone-acetate salt rats. Because endothelin 1 (ET-1) plays a major role in vascular dysfunction ...
Especificidade do apetite ao sódio: uma possível contribuição hormonal
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2006-08-24)
The hypothesis of a synergy between two hormones responsible for sodium
conservation, aldosterone and angiotensin II (ANG II), explains the expression of a
characteristic of sodium appetite, hypertonic NaCl intake, in a ...
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
(LIPPINCOTT WILLIAMS & WILKINS, 2011-04)
Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...