Artículos de revistas
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
Fecha
2011-04Registro en:
JOURNAL OF HYPERTENSION 29 (4): 706-715
0263-6352
Autor
Ocaranza, María Paz
Rivera, Paulina
Novoa, Ulises
Pinto, Melissa
González, Leticia
Chiong Lay, Mario
Lavandero González, Sergio
Jalil Milad, Jorge
Institución
Resumen
Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho kinase activity. However, the relationship between Rho kinase activation and ACE2 in hypertension is unknown.
Objective The role of the Rho kinase signaling pathway in both enzymatic activity and aortic gene expression of ACE2 in deoxycorticosterone acetate (DOCA) hypertensive rats was assessed in the present study.