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Mostrando ítems 11-20 de 151
Epidemiologia da leucemia linfocítica crônica e leucemia linfocítica crônica familiar
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2005-12-01)
Chronic lymphocytic leukemia (CLL) is a chronic lympho-proliferative desorder (CLPD) with peculiar epidemiologic characteristics. It is a disease of the elderly, which is very rare in under 30-year-old individuals and ...
Using wavelet sub-band and fuzzy 2-partition entropy to segment chronic lymphocytic leukemia images
(2018-03-01)
Histological images analysis is an important procedure to diagnose different types of cancer. One of them is the chronic lymphocytic leukemia (CLL), which can be identified by applying image segmentation techniques. This ...
Revisiting the role of interleukin-8 in chronic lymphocytic leukemia
(Nature Publishing Group, 2017-12)
The proliferation and survival of malignant B cells in chronic lymphocytic leukemia (CLL) depend on signals from the microenvironment in lymphoid tissues. Among a plethora of soluble factors, IL-8 has been considered one ...
Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi
(Taylor & Francis, 2015-01)
Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells ...
Intracytoplasmic filamentous inclusions and IGHV rearrangements in a patient with chronic lymphocytic leukemia
(Taylor & Francis Ltd, 2018-05)
Chronic lymphocytic leukemia (CLL) represents the most common leukemia in the Western world, accounting for 30-40% of all adult leukemias. The disease is characterized by a highly variable clinical course, ranging from ...
Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia
(American Society of Hematology, 2019-05-13)
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes. As a trade-off for its physiological function, AID also contributes to tumor development ...
Immunoglobulin gene rearrangements and mutational status in argentinian patients with chronic lymphocytic leukemia
(Elsevier Inc., 2013-08)
Background: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. The mutational status of the immunoglobulin heavy chain variable (IGHV) region represents one of the best prognostic markers and defines ...
Soluble RANKL production by leukemic cells in a case of chronic lymphocytic leukemia with bone destruction
(Taylor & Francis Ltd, 2016-01)
Receptor Activator for Nuclear Factor j B Ligand (RANKL) is a member of the TNF-a superfamily normally produced by osteoblasts and stromal cells, which activates its receptor RANK present on osteoclasts and osteoclast ...
Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells
(Taylor & Francis Ltd, 2019-04)
Chronic lymphocytic leukemia (CLL) is the most commontype of leukemia in adults, characterized by the expansionof a population of monoclonal CD5þB-lymphocytesthat accumulate in the blood, bone marrow, and secondarylymphoid ...
Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia
(Nature, 2021-06)
Hypogammaglobulinemia is the most frequently observed immune defect in chronic lymphocytic leukemia (CLL). Although CLL patients usually have low serum levels of all isotypes (IgG, IgM and IgA), standard immunoglobulin ...