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Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors
(2008)
Zinc and copper are indispensable trace metals for life with a recognized role as catalysts in enzyme actions. We now review evidence supporting the role of trace metals as novel allosteric modulators of ionotropic receptors: ...
How does confinement change ligand-receptor binding equilibrium? Protein binding in nanopores and nanochannels
(American Chemical Society, 2015-10)
We present systematic studies for the binding of small model proteins to ligands attached to the inner walls of long nanochannels and short nanopores by polymeric tethers. Binding of proteins to specific ligands inside ...
Voltage-controlled gating in a large conductance Ca2+-sensitive K(+)channel (hslo)
(NATL ACAD SCIENCES, 1997-05-13)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage- and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged ...
Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulum
(Sociedad de Biología de Chile, 2004)
Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
(Elsevier B.V., 2015)
Abstract: Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a
paradigm, this short overviewanalyzes the occurrence of structuralmotifswhich appear not only to be ...
Fatty acid regulation of voltage-and-ligand-gated ion channel function
(Frontiers, 2016)
Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the ...
A Novel Mechanism of Modulation of 5-HT3A Receptors by Hydrocortisone
(Cell Press, 2011-01)
Modulation of Cys-loop receptors by steroids is of physiological and therapeutical relevance. Nonetheless, its molecular mechanism has not been elucidated for serotonin (5-HT) type 3 receptors. We deciphered the mechanism ...