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Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency
(ENDOCRINE SOC, 2009)
Context: 21-Hydroxylase deficiency (21OHD) is caused by CYP21A2 gene mutations disrupting the adrenal 21-hydroxylase, P450c21. CYP21A2 mutations generally correlate well with the 21OHD phenotype, but some children with ...
MODELO MULTIGÉNICO DE IDENTIFICACIÓN DE MUJERES DE ALTO RIESGO A DESARROLLAR CÁNCER DE MAMA POR MEDIO DEL ANÁLISIS POLIMORFICO DE COMPT, CYP17, CYP1A1, CYP19 Y RECEPTOR DE ESTRÓGENO
(2011-04-15)
Background. In Mexico, between women with cancer, the breast cancer is in first
place like the cause of death. 65% of this women belong to the productive group
between 35 to 64 years of age. Furthermore, the number of ...
Efecto del calcitriol sobre la sintesis placentaria de citocinas pro- nflamatorias en la preeclampsia y regulación de CYP27B1 y CYP24A1 por TNF-IFN- IL-6 e IL -1
(2011-09-22)
Placenta is an important source and target of hormones that contribute to
immunological tolerance in pregnancy. It is known that in preeclampsia (PE), the
placenta 1,25-dihydroxyvitamin D3 (calcitriol) synthesis is low; ...
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas
(Walter de Gruyter & Co, 2008-01-01)
Background: Uterine leiomyomas are common, benign, smooth muscle tumors representing a significant public health problem. The aim of this study was to investigate CYP17A1, CYP19, and androgen (AR) polymorphisms, their ...
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas
(Walter de Gruyter & Co, 2008-01-01)
Background: Uterine leiomyomas are common, benign, smooth muscle tumors representing a significant public health problem. The aim of this study was to investigate CYP17A1, CYP19, and androgen (AR) polymorphisms, their ...
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
(NATURE PUBLISHING GROUPLONDON, 2012)
The impact of biogeographical ancestry, self-reported 'race/color' and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) ...