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Mostrando ítems 11-20 de 1064
Efecto del calcitriol sobre la sintesis placentaria de citocinas pro- nflamatorias en la preeclampsia y regulación de CYP27B1 y CYP24A1 por TNF-IFN- IL-6 e IL -1
(2011-09-22)
Placenta is an important source and target of hormones that contribute to
immunological tolerance in pregnancy. It is known that in preeclampsia (PE), the
placenta 1,25-dihydroxyvitamin D3 (calcitriol) synthesis is low; ...
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
(NATURE PUBLISHING GROUPLONDON, 2012)
The impact of biogeographical ancestry, self-reported 'race/color' and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) ...
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas
(Walter de Gruyter & Co, 2014)
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer
(Funpec-editora, 2015-01-01)
Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a ...
Investigation of the in vivo activity of CYP3A in Brazilian volunteers: comparison of midazolam and omeprazole as drug markers
(SPRINGER HEIDELBERG, 2008)
Objective This study compares midazolam with omeprazole as marker drugs for the evaluation of CYP3A activity in nine healthy self-reported white Brazilian volunteers. Methods Omeprazole was also used to evaluate the CYP2C19 ...
CYP1A1 , CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms
(2016-12-07)
AIM: To investigate the contribution of polymorphisms in the CYP1A1 , CYP2E1 and EPHX1 genes on sporadic colorectal cancer (SCRC) risk. Methods: Six hundred forty-one individuals (227 patients with SCRC and 400 controls) ...
Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
(Spandidos Publications, 2019)
CYP2D6 polymorphism and its clinical implications
(Pharmacological and Toxicological Aspects 2010:1-20, 2010)
CY P2D6 is the most important enzyme in the metabolism ofdrugsandisresponsibleforthe metabolism of25% of all drugs currently available on the market. CYP 2D6 is not only expressed in liver but also in gut and brain neurons, ...