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TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells
(John Wiley and Sons Ltd., 2018)
Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...
Increased nuclear β-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia
(Medicina Oral, Patologia Oral y Cirugia Bucal, 2015)
Background: Deregulation of β-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to ...
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells
(American Association for Cancer Research, 2012-02)
Purpose: To study Wnt/β-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the β-catenin-androgen receptor (AR) interaction. Experimental Design: We carried out β-catenin ...
Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers
(Taylor & Francis, 2010)
Wnt/β-catenin/T cell factor (TCF) pathway is activated in several types of human cancers, promoting cell growth and proliferation. Forkhead box containing protein class O (FOXO) transcription factors compete with TCF for ...
Expression profile of components of the beta-catenin destruction complex in oral dysplasia and oral cancer
(Medicina Oral, 2021)
Background: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50%
survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by
potentially ...
TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells
(John Wiley and Sons Ltd., 2018)
© 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism ...
CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and enhance cell survival
(2011)
β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
Simvastatin modulates β-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
(Polish Academy of Sciences, 2018)
© 2018 Polish Academy of Sciences. All rights reserved. The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional ...
Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
(Company of Biologists, 2011-06)
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal ...
HER2 and β-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations
(Springer, 2015-02)
In human breast cancer, β-catenin localization has been related with disease prognosis. Since HER2-positive patients are an important subgroup, and that in breast cancer cells a direct interaction of β-catenin/HER2 has ...