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Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human 3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles
(MDPI, 2018)
The wide tissue distribution of the adrenergic 3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ...
QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives
(Elsevier Science, 2009-12)
We establish useful models that relate experimentally measured biological activities of compounds to their molecular structure. The pED50 feeding inhibition on Spodoptera litura species exhibited by aurones, chromones, ...
Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study
(Hindawi Publishing Corporation, 2016-08-21)
Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these ...
Terpenes: Natural Products for Controlling Insects of Importance to Human Health?A Structure-Activity Relationship Study
(Hindawi Publishing Corporation, 2016-09)
Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these ...
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human 3-adrenergic receptor and anti-obesity and anti-diabetic profiles
(MDPI, 2018)
The wide tissue distribution of the adrenergic 3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ...
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles
(2018)
The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ...
Three-dimensional quantitative structure-activity relationships for a large series of potent antitubercular agents
(BENTHAM SCIENCE PUBL LTDEmirados Árabes Unidos, 2008)
Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition
(Future ScienceLondon, 2013-10)
Background: Sleeping sickness is a major cause of death in Africa. Since no secure treatment is available, the development of novel therapeutic agents is urgent. In this context, the enzyme trypanothione reductase (TR) is ...