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Telomere and Telomerase Biology
(Elsevier B.V., 2014-01-01)
Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA ...
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects
(AMER MEDICAL ASSOC, 1998)
Context.-Human immunodeficiency virus (HIV) infection has been associated with an increasing incidence of malignancy, and HIV-infected persons have an increased incidence of primary lung carcinoma compared with the general ...
Dysregulated expression of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells
(2016)
Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). ...
Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells
(2016)
Background: Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium ...
Expression profile of telomere-associated genes in multiple myeloma
(Wiley Blackwell Publishing, Inc, 2012-12)
To further contribute to the understanding of multiple myeloma, we have focused our research interests on the mechanisms by which tumour plasma cells have a higher survival rate than normal plasma cells. In this article, ...
Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line
(Associação Brasileira de Divulgação Científica, 2010-08-01)
Gastric cancer is the fourth most frequent type of cancer and the second cause of cancer mortality worldwide. The genetic alterations described so far for gastric carcinomas include amplifications and mutations of the ...
An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
(Spandidos Publication, 2017-05)
Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have ...