info:eu-repo/semantics/article
An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
Fecha
2017-05Registro en:
Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; et al.; An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome; Spandidos Publication; Oncology Letters; 13; 5; 5-2017; 3159-3162
1792-1082
CONICET Digital
CONICET
Autor
Gutierrez, Leandro German
Noriega, Maria Fernanda
Laudicina, Alejandro
Quatrin, Mariana
Bengió, Raquel María
Larripa, Irene Beatriz
Resumen
Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.