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Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study
(Wiley, 2018)
AimWe aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR).
MethodsA double blind, multicenter, randomized trial ...
EFECTOS DE METFORMINA SOBRE LOS NIVELES DE NITROOXIDACIÓN EN PACIENTES HIPERTENSOS CON SÍNDROME METABÓLICO
(2011-05-30)
Introduction. Metabolic syndrome (MS) is a cluster of risk factors for developing type 2 diabetes and cardiovascular disease characterized by insulin resistance and compensatory hyperinsulinemia associated with disorder ...
In vitro anti-echinococcal and metabolic effects of metformin involve activation of AMP-activated protein kinase in larval stages of Echinococcus granulosus
(Public Library of Science, 2015-05)
Metformin (Met) is a biguanide anti-hyperglycemic agent, which also exerts antiproliferative effects on cancer cells. This drug inhibits the complex I of the mitochondrial electron transport chain inducing a fall in the ...
Metformin prevents the increase of nitric oxide and lipid peroxidation induced by dehydroepiandrosterone in early pregnant mice
(Bentham Science Publishers, 2013-09)
The aim of this work was to study the effects of dehydroepiandrosterone (DHEA) and metformin (M) on nitric oxide (NO) system and oxidative stress in embryo implantation sites of early pregnant mice. The biguanide M is used ...
Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis
(Cambridge University Press, 2022-01-21)
Alveolar echinococcosis (AE) is a severe disease caused by Echinococcus multilocularis. Its chemotherapeutic treatment is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, it ...
Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production
(Blackwell Publishing Ltd, 2021-05)
The direct correlation between Sertoli cell number and sperm production capacity highlights the importance of deciphering external factors that modify Sertoli cell proliferation. A growing body of evidence in vitro suggests ...
Metformin counteracts the effects of FSH on rat Sertoli cell proliferation
(BioScientifica, 2018-05)
Metformin (MET) is one of the most widely used anti-hyperglycemic agents for treating patients with type 2 diabetes and it has started to be used in pediatric population at ages when Sertoli cells are still proliferating. ...
Metformin promotes autophagy in Echinococcus granulosus larval stage
(Elsevier Science, 2018-09)
Cystic echinococcosis is a neglected parasitic disease caused by the larval stage of Echinococcus granulosus for which an effective treatment is not yet available. Since autophagy constitutes a homeostatic mechanism during ...
Metformin has a direct effect on ovarian cells that is dependent on organic cation transporters
(Elsevier Ireland, 2020-01)
Metformin (MET) is the most widely prescribed hypoglycemic drug in type 2 diabetes and Polycystic Ovary Syndrome. Besides its effects on glucose metabolism, MET exerts beneficial effects on these patients? fertility. ...
Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin
(European Society of CardiologyReino Unido, 2021-07-07)
Objective
Recent European Guidelines for Diabetes, Prediabetes and Cardiovascular Diseases introduced a shift in managing patients with type 2 diabetes at high risk for or established cardiovascular (CV) disease by ...