info:eu-repo/semantics/article
Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production
Fecha
2021-05Registro en:
Rindone, Gustavo Marcelo; Gorga, Agostina; Pellizzari, Eliana Herminia; Camberos, Maria del Carmen; Galardo, Maria Noel Lujan; et al.; Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production; Blackwell Publishing Ltd; Andrology; 9; 3; 5-2021; 965-976
2047-2927
CONICET Digital
CONICET
Autor
Rindone, Gustavo Marcelo
Gorga, Agostina
Pellizzari, Eliana Herminia
Camberos, Maria del Carmen
Galardo, Maria Noel Lujan
Da Ros, Vanina Gabriela
Buffone, Mariano Gabriel
Meroni, Silvina Beatriz
Riera, Maria Fernanda
Resumen
The direct correlation between Sertoli cell number and sperm production capacity highlights the importance of deciphering external factors that modify Sertoli cell proliferation. A growing body of evidence in vitro suggests that metformin, the main pharmacological agent for type 2 diabetes treatment in children, exerts anti-proliferative effects on Sertoli cells.