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The effects of male age on sperm DNA damage in an infertile population
(2007-11-01)
The objective was to investigate the influence of age on sperm DNA damage. Semen samples were collected from 508 men in an unselected group of couples attending infertility investigation and treatment. DNA fragmentation ...
The effects of male age on sperm DNA damage in an infertile population
(2007-11-01)
The objective was to investigate the influence of age on sperm DNA damage. Semen samples were collected from 508 men in an unselected group of couples attending infertility investigation and treatment. DNA fragmentation ...
Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women
(Biomed Central Ltd, 2015-01-15)
Background: Pregnant women with mild gestational hyperglycemia present high risk for hypertension, obesity and hyperglycemia, and appeared to reproduce the model of metabolic syndrome in pregnancy, with hyperinsulinemia ...
Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes
(Wiley-Blackwell, 2014-07-01)
Problem The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in ...
Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms
(J Rheumatol Publ CoTorontoCanadá, 2014)
The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight
(ELSEVIER SCIENCE SA, 2010)
Solar radiation sustains and affects all life forms on Earth. The increase in solar UV-radiation at environmental levels, due to depletion of the stratospheric ozone layer, highlights serious issues of social concern. This ...
Reciprocal regulation between alternative splicing and the DNA damage response
(Sociedade Brasileira de Genética, 2020-03)
Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, ...
Toxic and genotoxic effects of trivalent and hexavalent chromium - A review
(2005-06-01)
During the last years, the emission of heavy metals to the environment has increased, causing a severe negative impact to the ecosystems and seriously compromising human health due to their mutagenic potential. Tri- (III) ...
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line
(2020-12-01)
Chronic inflammation resulting from Helicobacter pylori (H. pylori) infection, the major risk factor for gastric cancer, results in increased release of reactive oxygen species (ROS), promoting oxidative stress and DNA ...
Genotoxicity of the herbicide imazethapyr in mammalian cells by oxidative DNA damage evaluation using the Endo III and FPG alkaline comet assays
(Springer Heidelberg, 2017-04)
We evaluated the role of oxidative stress in the genotoxic damage induced by imazethapyr (IMZT) and its formulation Pivot® in mammalian CHO-K1 cell line. Using the alkaline comet assay, we observed that a concentration of ...