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How membrane lipids control the 3D structure and function of receptors
(AIMS Press, 2018)
Abstract: The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface ...
Reduced caveolae density in arteries of SHR contributes to endothelial dysfunction and ROS production
(Nature Publishing Group, 2019-04-30)
Caveolae are plasma membrane invaginations enriched with high cholesterol and sphingolipid content; they also contain caveolin proteins in their structure. Endothelial nitric oxide synthase (eNOS), an enzyme that synthesizes ...
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
(2019-07-26)
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a ...
Increased placental mitochondrial fusion in gestational diabetes mellitus: An adaptive mechanism to optimize feto-placental metabolic homeostasis?
(2020-03-05)
Introduction Gestational diabetes mellitus (GDM), a common pregnancy disorder, increases the risk of fetal overgrowth and later metabolic morbidity in the offspring. The placenta likely mediates these sequelae, but the ...
VvGONST-A and VvGONST-B are Golgi-localised GDP-sugartransporters in grapevine (Vitis vinifera L.)
(Elsevier, 2015)
tPlant nucleotide-sugar transporters (NSTs) are responsible for the import of nucleotide-sugar substratesinto the Golgi lumen, for subsequent use in glycosylation reactions. NSTs are specific for either GDP-or UDP-sugars, ...
A sexually dimorphic hypothalamic response to chronic highfat diet consumption
(Nature Publishing Group, 2016)
In this review, we discuss the observations that, following chronic high-fat diet (HFD) exposure,
male mice have higher levels of saturated fatty acids (FAs) and total sphingolipids, whereas lower
amounts of polyunsaturated ...
Sphingosine kinase signalling in immune cells
(SABER ULA, 2008)
Lipidomics Analysis Of Follicular Fluid By Esi-ms Reveals Potential Biomarkers For Ovarian Endometriosis
(SPRINGER/PLENUM PUBLISHERSNEW YORK, 2015)
Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel
(Biochemical and Biophysical Research Communications, 2013)
Sphingosine kinase signalling in immune cells
(SABER ULA, 2008)