Artículo de revista
A sexually dimorphic hypothalamic response to chronic highfat diet consumption
Fecha
2016Registro en:
International Journal of Obesity Volumen: 40 Número: 2 Páginas: 206-209 (2016)
DOI: 10.1038/ijo.2015.114
Autor
Morselli, E.
Frank, A. P.
Palmer, B. F.
Rodriguez Navas, C.
Criollo Céspedes, Alfredo
Clegg, D. J.
Institución
Resumen
In this review, we discuss the observations that, following chronic high-fat diet (HFD) exposure,
male mice have higher levels of saturated fatty acids (FAs) and total sphingolipids, whereas lower
amounts of polyunsaturated FAs in the central nervous system (CNS) than females. Furthermore,
males, when compared with female mice, have higher levels of inflammatory markers in the
hypothalamus following exposure to HFD. The increase in markers of inflammation in male mice is
possibly due to the reductions in proliferator-activated receptor gamma coactivator 1 alpha (PGC-1
alpha) and estrogen receptor alpha (ER alpha), which is not recapitulated in female mice.
Consistently, hypothalamic inflammation is induced both in male and female ER alpha total-body
knockout mice when exposed to a HFD, thus confirming the key role of ER alpha in the regulation
of HFD-induced hypothalamic inflammation. Finally, the HFD-induced depletion of hypothalamic ER
alpha is associated with dysregulation in metabolic homeostasis, as evidenced by reductions in
glucose tolerance and decrements in myocardial function.