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Effect of metformin on markers of epithelial mesenchymal transition induced by TGF-beta in mammary cells
(Spandidos Publ Ltd, 2014)
Metformina na gestação: reflexão à luz da literatura e seu uso no hospital das clínicas da UFMG
(Universidade Federal de Minas GeraisUFMG, 2017-07-28)
Introduction: The incidence of diabetes in pregnancy increases worldwide. Glycemic uncontrol can trigger unfavorable maternal, fetal and neonatal outcomes. When the initial treatment with physical activity and hypocaloric ...
Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment
(Elsevier, 2022)
Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and spinal cord, resulting in the displacement of ...
Metformin for the treatment of breast cancer: Protocol for a scoping review of randomised clinical trials
(2021-08-09)
Introduction Innovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic ...
Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats
(2019-04-30)
Background: Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa ...
Lycopene improves the metformin effects on glycemic control and decreases biomarkers of glycoxidative stress in diabetic rats
(2020-01-01)
Introduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability ...
Correction: Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis
(Public Library of Science, 2017-03)
Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy ...
Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis
(Public Library of Science, 2017-02)
Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy ...
Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells
(Pergamon-Elsevier Science Ltd, 2019-05-10)
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, ...