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Nanodrug Delivery Systems for Dermal and Transdermal Photosensitizer Drugs
(2017-03-29)
Skin is the largest organ in the human body and functions as a protective barrier. Molecules can penetrate the skin by three main routes: (1) intracellular (across the corneocytes), (2) intercellular lipids, and (3) ...
The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination
(MDPI, 2021)
The World Health Organization estimates that the pandemic caused by the SARS-CoV-2 virus claimed more than 3 million lives in 2020 alone. This situation has highlighted the importance of vaccination programs and the urgency ...
Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine
(2021-11-01)
Artemether (ART) and lumefantrine (LUM) are the gold standard antimalarial drugs used for the treatment of malaria in children and pregnant women. Typically, ART and LUM are delivered orally in the form of a combined tablet, ...
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
(Springer New York LLC, 2017)
© 2017, American Association of Pharmaceutical Scientists. Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last ...
Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome
(Blackwell Publishing Ltd, 2018)
© 2018 John Wiley & Sons Ltd Objective: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes ...
Fenómenos de transporte aplicados a productos de interés farmacéutico
(Universidad Nacional de San Luis, 2007-12)
El diseño de fármacos de aplicación transdermal requiere el conocimiento previo de los fenómenos de difusión por los que se ve afectado el principio activo para alcanzar la circulación sanguínea. Estos conceptos se aplicaron ...
Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome
(John Wiley & Sons, 2019)
Objective: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including ...
Pharmacokinetics of a novel spot-on formulation of praziquantel for dogs
(Elsevier Science, 2017-05)
Praziquantel (PZQ) is an anthelmintic drug used both in humans and animals that can be administered through various routes. There are transdermal formulations for cats, but only oral or subcutaneous dosage forms for dogs. ...
Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
(American Scientific Publishers, 2013-02)
Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl ...